Conheça os docentes do Programa de Pós-Graduação em Bioquímica
Prof. Dr. Adriano Silva Sebollela
Vacancies: 4 CV
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Research interest: Toxic protein oligomers are the main responsible for synaptic loss and the subsequent cognitive deficit in CNS disorders, such as Alzheimer's, Parkinson's, and prion diseases. As a consequence, the interaction of oligomers with neurons has become a strategic target for the development of innovative therapeutic interventions. On the other hand, the structure of these toxic species has not yet been unraveled, as well as the molecular mechanisms by which oligomers exert their toxicity. Our main objective is to understand the molecular basis of the toxicity of disease-associated protein oligomers, using as a main tool humanized scFv-type artificial antibodies capable of distinguishing toxic oligomers from non-toxic aggregates. We have studied in detail the neuroprotective properties of toxic anti-oligomer scFv's using various CNS models. We hope that reagents with high diagnostic and therapeutic potential against untreated oligomer-induced neuropathologies will derive from our studies.
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Prof. Dr. Antonio José da Costa Filho
Linha de Pesquisa: Possui graduação em Física pela Universidade de São Paulo (1994). Seu projeto de doutoado foi desenvolvido tanto em São Carlos, sob a orientação do Prof. Otaciro Nascimento, e em Ithaca (EUA), onde passou 3 anos como aluno visitante na Cornell University, trabalhando sob a orientação do Prof. Jack Freed. Durante seu doutorado, trabalhou no desenvolvimento de novos métodos de ressonância magnética eletrônica para o estudo de: (1) interações lipídio-proteína, (2) a estrutura dinâmica de membranas lipídicas e (3) centros metálicos na estrutura de proteínas. Em 2001 recebeu o título de Doutor em Física pela Universidade de São Paulo e passou a atuar como Professor Assistente na USP (Campus São Carlos). Atualmente é Professor Titular da USP-Ribeirão Preto e seus interesses de pesquisa envolvem a investigação de interações entre biomoléculas com ênfase em como a interação entre proteínas e seus ligantes (substratos, inibidores e membranas) pode levar à modulação da função proteica. Recentemente, também se interessou pelo comportamento estrutural de proteínas envolvidas nas vias secretoras não convencionais da célula, em particular as chamadas Golgi Reassembly and Stacking Proteins (GRASPs). Para atingir esses objetivos, seu grupo faz uso de uma abordagem combinada e interdisciplinar de técnicas experimentais, como ressonância magnética, dicroísmo circular e microcalorimetria.
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Número de vagas: 02
Prof. Dr. Arthur Henrique Cavalcante de Oliveira
Vacancies: 4 CV
Research interest: Bachelor in Biological Sciences from Paulista State University Júlio de Mesquita Filho (1997), Master in Biochemistry from University of São Paulo (2000) and PhD in Cellular and Molecular Biology from University of São Paulo (2004). He is a PhD Professor in the Department of Chemistry at the Faculty of Philosophy Sciences and Letters of Ribeirão Preto (USP) since October 2005. His work is focused on​​Biochemistry and Molecular Biology, mainly investigating protein structure and function, especially the parasitic protozoan Leishmania. The characterization of targets involves proteomic analysis, cloning of coding sequences, site-directed mutation, biochemical and biophysical characterization, and studies of functional activities, especially by evaluating virulence with overexpressive parasites of target proteins are also target of interest at Prof. Arthur's lab.
Prof. Dr. Carlos Arterio Sorgi
Vacancies: 4 CV
Research interest: Bachelor in Biological Sciences from Paulista State University Júlio de Mesquita Filho (1997), Master in Biochemistry from University of São Paulo (2000) and PhD in Cellular and Molecular Biology from University of São Paulo (2004). He is a PhD Professor in the Department of Chemistry at the Faculty of Philosophy Sciences and Letters of Ribeirão Preto (USP) since October 2005. His work is focused on​​Biochemistry and Molecular Biology, mainly investigating protein structure and function, especially the parasitic protozoan Leishmania. The characterization of targets involves proteomic analysis, cloning of coding sequences, site-directed mutation, biochemical and biophysical characterization, and studies of functional activities, especially by evaluating virulence with overexpressive parasites of target proteins are also target of interest at Prof. Arthur's lab.
Prof. Dr. Fausto Bruno dos Reis Almeida
Vacancies: 4 CV
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Research interest: PhD Professor at the Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP / USP), in the Integral Dedication Regime for Teaching and Research (RDIDP). He completed postdoctoral internships at the Department of Microbiology and Immunology - Albert Einstein College of Medicine of New York (2014-2015) and at the Department of Cellular and Molecular Biology and Pathogenic Bioagents - USP (2013-2016). Biologist (UFG - 2006), Master (2009) and Doctor (2013) in Cellular and Molecular Biology at FMRP / USP, with sandwich internship at the University of Texas - USA (2010). His studies are focused on extracellular vesicles as a factor of fungal virulence. The main areas of activity of the group are: studies of biochemistry, microbiology, pathogenesis and cell biology of fungal infectious diseases. We investigate mechanisms of unconventional secretion in fungi, aiming to elucidate the pathogenesis and biology of infectious diseases, as well as the host fungus interaction.
Prof. Dr. Francisco Assis Leone
Vacancies: 4 CV
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Research interest: Structure and function of ions translocating ATPases - This research field aims to characterize both kinetically and biochemically (Na +, K +) - ATPase and the possible isoforms existing in the gill tissue of different species of crustaceans captured in their natural habitat or artificially acclimated in different salinities. Professor Francisco's research are focused to contribute to a better understanding of the biochemical and physiological adaptations associated with crustacean colonization of the freshwater environment, as well as to the understanding of the mechanisms of regulation of enzyme activity in response to alteration of salinity of the external environment.
Prof. Dr. Germán Gustavo Sgro
Vacancies: 4 CV
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Research interest: 1 - Molecular analysis of calcineurin in human pathogenic fungi; 2 - Identification of genes preferentially expressed in the pathogenic phase of P. brasiliensis; 3 - Construction of industrial Saccharomyces cerevisiae strains capable of metabolizing xylose; 4 - Expression of Trichoderma reesei and Aspergillus niger genes grown in sugarcane bagasse.
Prof. Dr. Gustavo Henrique Goldman
Vacancies: 4 CV
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Research interest: 1 - Molecular analysis of calcineurin in human pathogenic fungi; 2 - Identification of genes preferentially expressed in the pathogenic phase of P. brasiliensis; 3 - Construction of industrial Saccharomyces cerevisiae strains capable of metabolizing xylose; 4 - Expression of Trichoderma reesei and Aspergillus niger genes grown in sugarcane bagasse.
Profª. Drª. Isis do Carmo Kettelhut
Vacancies: 4 CV
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Research interest: The laboratory research of Dr. Isis is focused on the study of hormonal, nutritional and neural control of protein, lipid and carbohydrate metabolism in different physiological and pathological models. We investigated the regulation of protein synthesis and degradation pathways in skeletal and cardiac muscle and studied the control of glycerol-3-phosphate (G3P) generation pathways in white and brown adipose tissues, and in the liver.
Profª. Drª. Lívia Soares Zaramela
Vacancies: 4 CV
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Research interest: The laboratory research of Dr. Isis is focused on the study of hormonal, nutritional and neural control of protein, lipid and carbohydrate metabolism in different physiological and pathological models. We investigated the regulation of protein synthesis and degradation pathways in skeletal and cardiac muscle and studied the control of glycerol-3-phosphate (G3P) generation pathways in white and brown adipose tissues, and in the liver.
Profª. Drª. Lucia Helena Faccioli
Vacancies: 4 CV
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Research interest: Drª Lucia's laboratory is focused on Immunology, mainly studying inflammatory response and role of lipid mediators in pulmonary infections by bacteria and parasites. It also investigates innate venom-induced immune responses, especially scorpions. In addition, it works with the investigation of natural products with anti-inflammatory activity and new pharmaceutical formulations focusing on controlled release systems of lipid mediators.
Profª. Drª. Luciane Carla Alberici
Vacancies: 4 CV
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Research interest: Dr Luciane has extense experience in Biochemistry and Metabolism, acting mainly in the study of mitochondrial metabolism and oxidative stress in pathologies such as cancer, dyslipidemia, obesity, steatosis and diabetes. Has experience in exercise biochemistry. The laboratory is focused on the study of mitochondrial bioenergetics and oxidative stress as well as the neural, hormonal and nutritional control of autophagy.
Prof. Dr. Marcelo Damário Gomes
Vacancies: 4 CV
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Reserach interest: Graduated in Pharmacy-Biochemistry from the State University of Londrina (1987), Master in Molecular Biology from the Federal University of São Paulo (1993), PhD in Molecular Biology from the Federal University of São Paulo (1997) and Postdoctorate at Cell Biology - Harvard Medical School (1999-2003). The laboratory has as its research line cell proteolysis, identification of substrates and inhibitors for oligopeptidases and also the molecular basis of participation of ubiquitins ligases in muscle atrophy.
Profª. Drª. Maria Cristina Nonato
Vacancies: 4 CV
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Research interest: Structural biology in protein structure-based drug planning. Identifying bioactive molecules as a prototype for drug development against neglected diseases, rare diseases, malaria and cancer is a goal for Drª. Maria Cristina. Her research is focused on the validation, characterization of the mechanism of action and search for target protein ligands. To achieve the objective we use a range of in vitro and in silico tools involving functional and structural characterization studies, biophysics and biochemistry, with emphasis on X-ray crystallography. Within this line of research also stands out the development and application of tools for determining power and characterization of the mechanism of action of ligands / inhibitors.
Profª. Drª. Maria de Lourdes Teixeira de Moraes Polizeli
Vacancies: 4 CV
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Research interest: Drª. Polizeli's studies begin with the prospecting of filamentous fungi aiming at the search for new enzyme producing microorganisms with biotechnological applications, such as lipases, xylanases, cellulases, amylases, phytases, among others. Her laboratory also develops purification techniques and biochemical characterization of the studied enzymes, aiming at a better structural understanding of these enzymes. We also have molecular biology techniques for the heterologous expression of some proteins using the expression vectors for Pichia pastoris and Aspergillus nidulans. The heterologous expression of proteins is very important when the functional study of proteins is intended. Thus, the target of the laboratory goes from the prospecting of new strains (homologous or heterologous) to the enzymatic production in bench or large scale using reactors for ruminant and monogastric feed application, biodiesel production, pulp biobleaching and / or enzymatic cocktail formation aiming at the degradation of plant cell walls and agro-industrial residues, emphasizing on bioethanol production
Prof. Dr. Pietro Ciancaglini
Vacancies: 4 CV
Reseach interest: Physiology Bachelor - University of Sheffield-UK (1983) and PhD in Biophysics (The Oxford Research Unit Oxford-UK (1987)). He did postdoctoral studies in Structural Biology at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany (1987-1991) and Molecular Biology at the Institut fur Medizinische Mikrobiologie, Universitat Mainz, Alemnaha (1991-1993). He was a Visiting Professor at the Department of Physics, IBILCE-UNESP (1993-1996) and entered the University of São Paulo in 1996. Since 2017 he has been a Full Professor at the Department of Chemistry-FFCLRP at the University of São Paulo (Ribeirão Preto campus). He has experience in the area of ​​Biophysics and the main focus of his research is the Structure and Function of Proteins, acting mainly on the following themes: directed evolution of proteins, engineering of enzymes of industrial interest, nanotechnology and biomimetic systems.
Prof. Dr. Richard John Ward
Vacancies: 4 CV
Reseach interest: Physiology Bachelor - University of Sheffield-UK (1983) and PhD in Biophysics (The Oxford Research Unit Oxford-UK (1987)). He did postdoctoral studies in Structural Biology at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany (1987-1991) and Molecular Biology at the Institut fur Medizinische Mikrobiologie, Universitat Mainz, Alemnaha (1991-1993). He was a Visiting Professor at the Department of Physics, IBILCE-UNESP (1993-1996) and entered the University of São Paulo in 1996. Since 2017 he has been a Full Professor at the Department of Chemistry-FFCLRP at the University of São Paulo (Ribeirão Preto campus). He has experience in the area of ​​Biophysics and the main focus of his research is the Structure and Function of Proteins, acting mainly on the following themes: directed evolution of proteins, engineering of enzymes of industrial interest, nanotechnology and biomimetic systems.
Prof. Dr. Roberto do Nascimento Silva
Vacancie: 2 CV
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Research interest: Dr. Roberto's laboratory research is focused on the study of fungi, specifically the species Trichoderma reesei. The studies regard transcriptional regulation and systemic biology for the understanding of regulatory networks aiming at the deconstruction of plant biomass, which can be widely used for ethanol production as well as for several industrial applications. In this context, laboratory studies use functional genomics to investigate transcriptional and signaling mechanisms involving the production of cellulases and xylanases in the T. reesei fungus. In addition to studies with filamentous species, the group's interest is also based on the study of Saccharomyces cerevisiae sugars transporters for engineering strains of biotechnological interest.
Prof. Dr. Sérgio Akira Uyemura
Vacancies: 4 CV
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Research interest: Bioenergetic and molecular studies of mitochondrial components of microorganisms. Mitochondria are important cellular organelles, which are responsible not only for the conversion not only of nutritive components into energy. In addition to providing cellular energy, mitochondria are involved in other functions, such as signaling, cell differentiation and cell death, as well as maintaining control of the cell cycle and cell growth. Mitochondria have been implicated in various pathophysiology, mitochondrial syndromes, cardiac dysfunction, obesity, toxicological processes and others. For the past 25 years, our laboratory has been studying the importance of different mitochondrial components for energy and redox metabolism, as well as the participation in the pathogenesis of the opportunistic fungus Aspergillus fumigatus.
Profª. Drª. Tie Koide
Vacancies: 4 CV
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Research interest: Systems biology is the branch of science that seeks to understand biological organisms at all levels, from the characterization of their constituent parts (genes, RNAs, proteins, metabolites), the elucidation of interconnections between the different members of these interaction networks, to the understanding of the organism as a whole. Genomic-scale technologies that exploit transcriptome, proteome, protein-protein, protein-DNA, protein-RNA interactions, among others, represent powerful tools for systemic analysis. However, each of these individual data sets does not reflect a global view of cellular behavior, as the complexity of living organisms is an emerging property, inherent not only in genes, RNAs, proteins, or metabolites, but is a consequence of their actions. and interactions. To meet this challenge, our laboratory uses Halobacterium salinarum NRC-1 halophilic archaea as a model. This organism is very important from an evolutionary point of view because it presents the basic architecture of prokaryotes while the molecular mechanisms resemble those of eukaryotes, in addition to the great potential for biotechnological and industrial applications. Using Bioinformatics tools combined with new technologies in Biology, our group seeks the functional and structural characterization of potential non-coding RNAs (ncRNAs), analysis of protein-RNA and RNA-RNA interactions and the integration of all this information with the aim of understand more fully the overall behavior of the cell
Prof. Dr. Vanderlei Rodrigues
Vacancies: 4 CV
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Research interest: Dr. Vanderlei is a MD Doctor from the University of São Paulo (1974), Biologist Bachelor from the University of São Paulo (1970), a master's degree in Biochemistry from the University of São Paulo (1978) and PhD in Biochemistry from the University of São Paulo (1983). Postdoctoral research in molecular biology of parasites. National Institute for Medical Research, London (1985-1987). The laboratory has as its research lines the modulation of proteasome activity during the development of Schistosoma manson and Characterization of gene expression of the ubiquitin-proteasome proteolytic pathway during the development of this parasite.
Profª. Drª. Vanessa Carregaro Pereira
Vacancies: 4 CV
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Research interest: Bachelor in Biological Sciences Medical Modality from Barão de Mauá University Center (1999), Master's degree in Basic and Applied Immunology from the University of São Paulo (2005) and PhD in Basic and Applied Immunology from the Faculty of Medicine of Ribeirão Preto-University of São Paulo (2009). Drª Vanessa has extense experience in Immunology, focusing on Cellular Immunology, acting on the following subjects: parasite-host interaction, Innate Immunity, Adaptive Immunity, Immune Response Regulation. Her laboratory is focused on the study of Inflammatory Response Regulatory mechanisms in the severity of Visceral Leishmaniasis and the study of the role of adenosine receptor A2A in the suppressive effect of CD4 + CD39 + cells on experimental visceral leishmaniasis (VL).
Prof. Dr. Vitor Marcel Faça
Vacancies: 4 CV
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Reseach interest: Biomarkers are indicators of a specific biological state, with applications in diagnosis, therapy or genetic manipulation. Biomarkers may be proteins, antibodies, nucleic acids or metabolites. The Proteomic Cancer Laboratory is focused on biomarkers studies aiming at the diagnosis and therapy of mestastatic cancer. Cancer metastasis is responsible for most cancer deaths. Thus, the most effective methods for improving cancer morbidity and mortality rates are early detection, prevention and treatment of metastasis. Using modern tools of detailed and directed proteomic analysis, together with protein fractionation techniques and rigorous bioinformatic analysis, several cell lines derived from tumors of epithelial origins such as lung, breast, pancreas, ovary and prostate, induced in vitro to Metastasis process. Biomarkers identified in vitro are validated in clinical patient samples and thus can be used as targets for therapy and / or diagnosis of metastatic cancer. The same approach used to study cancer metastasis may be employed to identify candidate biomarkers in other relevant diseases or organisms.